Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene

J Med Chem. 1998 Jul 30;41(16):2928-31. doi: 10.1021/jm980048b.
No abstract available

MeSH terms

  • Administration, Oral
  • Animals
  • Biological Availability
  • Bone Density / drug effects
  • Breast Neoplasms / pathology
  • Cell Division / drug effects
  • Cholesterol / blood
  • Estrogen Antagonists / administration & dosage
  • Estrogen Antagonists / metabolism
  • Estrogen Antagonists / pharmacokinetics
  • Estrogen Antagonists / pharmacology*
  • Ethinyl Estradiol / metabolism
  • Female
  • Humans
  • Hypolipidemic Agents / metabolism
  • Hypolipidemic Agents / pharmacology
  • Neoplasms, Hormone-Dependent / pathology
  • Organ Size / drug effects
  • Ovariectomy
  • Pyrrolidines / administration & dosage
  • Pyrrolidines / metabolism
  • Pyrrolidines / pharmacokinetics
  • Pyrrolidines / pharmacology*
  • Rats
  • Receptors, Estrogen / agonists*
  • Receptors, Estrogen / antagonists & inhibitors*
  • Tetrahydronaphthalenes / administration & dosage
  • Tetrahydronaphthalenes / metabolism
  • Tetrahydronaphthalenes / pharmacokinetics
  • Tetrahydronaphthalenes / pharmacology*
  • Tumor Cells, Cultured
  • Uterus / drug effects

Substances

  • Estrogen Antagonists
  • Hypolipidemic Agents
  • Pyrrolidines
  • Receptors, Estrogen
  • Tetrahydronaphthalenes
  • Lasofoxifene
  • Ethinyl Estradiol
  • Cholesterol